Title: Phyllodes Tumors of the Breast: Clinicopathological Evaluation of 27 Cases and Review of the Literature
Authors: A. khattabi -M.Zemmari -Pr M. Bendahhou Idrissi- Pr C.Bouchikhi - Pr S.Errarhay - Pr N.Mamouni - Pr A.Banani
Volume: 9
Issue: 8
Pages: 86-91
Publication Date: 2025/08/28
Abstract:
: Introduction: Phyllodes tumors of the breast are rare fibroepithelial neoplasms that account for less than 1% of all breast tumors. They originate from the periductal stromal cells and exhibit a wide spectrum of biological behavior, ranging from benign to malignant forms. These tumors are characterized by rapid growth and can reach large sizes, often leading to significant breast asymmetry.Clinically, phyllodes tumors may present as painless, well-circumscribed breast masses that are sometimes mistaken for fibroadenomas. However, unlike fibroadenomas, phyllodes tumors have a higher propensity for local recurrence and, in rare cases, distant metastasis. Histologically, they are classified into benign, borderline, and malignant subtypes . The primary treatment for phyllodes tumors is surgical excision with wide margins to reduce the risk of recurrence. While benign tumors have an excellent prognosis, borderline and malignant forms require close follow-up due to the potential for recurrence and metastasis. Objective : Phyllodes tumors are rare biphasic tumors composed of epithelial and stromal components, representing less than 1% of all breast tumors. Histological confirmation is required to establish the diagnosis. The World Health Organization (WHO) classifies these tumors into three categories: benign, borderline, and malignant. Although typically benign, both the stromal and epithelial components have the potential to progress to malignancy. This descriptive study aims to present cases of phyllodes tumors and evaluate their clinicopathological characteristics based on existing literature. Materials and Methods :This is a retrospective study conducted in the gynecology obstetrics department I at CHU Hassan II between 2021 and 2024 of 39 cases of phyllodes tumors histologically certified. Results : All patients were female, with a mean age of 37,2 years. Among the 39 tumors identified, 32 (82.05%) were classified as benign, 3 (7.69%) as borderline, and 4 (10,26%) as malignant phyllodes tumors. The average consulting time was 12 months. The average tumor size was 4 cm. Surgical treatment was conservative in 78.4% (lumpectomy) and radical in 21.6% (mastectomy). Conclusion: Phyllodes tumors, often developing at a young age and can rapidly grow into large masses, may be clinically and pathologically misidentified as benign lesions. Diagnosis is established through pathology and immunohistochemistry. Surgical extended resection is the treatment of choice. These tumors play a significant role in breast surgery and pathology.