Title: Pharmacological Activities Of Azadirachta Indica (Neem) And Mangifera Indica (Mango): A Comparative Review
Authors: Ahmed Attahir
Volume: 9
Issue: 8
Pages: 221-226
Publication Date: 2025/08/28
Abstract:
Medicinal plants remain critical to healthcare worldwide and continue to inspire modern drug discovery. Azadirachta indica (neem) and Mangifera indica (mango) are two tropical species with long histories of use in traditional medicine across Asia and Africa. Both are pharmacologically versatile, supported by extensive phytochemical diversity. This review provides a comprehensive comparative analysis of their bioactive constituents and therapeutic activities. The discussion highlights four key compounds: nimbolide and azadirachtin from neem, and mangiferin and 3?-taraxerol from mango. Pharmacological activities considered include antidiabetic, anticancer, antioxidant, anti-inflammatory, antimicrobial, hepatoprotective, cardioprotective, and neuroprotective effects. Neem demonstrates pronounced efficacy in antimicrobial and cytotoxic applications, while mango excels in oxidative stress modulation, metabolic regulation, and cardiovascular protection. The review also examines evidence for polyherbal formulations that combine neem and mango extracts, emphasizing potential synergistic interactions in managing chronic and infectious diseases. Challenges in standardization, safety evaluation, bioavailability, and clinical translation are highlighted. Neem and mango emerge not only as traditional remedies but also as promising contributors to modern integrative medicine and future drug discovery.