Title: Aggregation And Adhesion Characteristics Of Platelets In Autoimmune Conditions: A Critical Review
Authors: Ruziyev Zarif Muxammadovich
Volume: 9
Issue: 9
Pages: 40-43
Publication Date: 2025/09/28
Abstract:
Platelets are integral not only to the maintenance of hemostasis but also serve as active mediators in immunological and inflammatory pathways. They express a wide range of adhesion molecules, receptors, and signaling proteins that allow them to interact dynamically with vascular and immune cells. In autoimmune disorders such as systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), and antiphospholipid syndrome (APS), growing evidence indicates that platelet behavior is significantly altered, leading to functional reprogramming that extends beyond normal clotting functions. These alterations include increased expression of adhesion receptors, heightened responsiveness to proinflammatory stimuli, and excessive release of bioactive mediators, all of which contribute to a sustained prothrombotic environment. Such changes are closely linked to vascular injury, immune activation, and an elevated risk of both arterial and venous thrombotic events. This review synthesizes current knowledge on how autoimmune pathologies influence platelet adhesion and aggregation, with a focus on the molecular interactions and intracellular signaling mechanisms involved. In addition, it evaluates the contribution of these dysregulated processes to thromboinflammatory complications and discusses emerging therapeutic strategies aimed at modulating platelet-immune interactions while preserving essential hemostatic function.