Title: Association Rare Du Mutation Du Facteur V Leiden Et Polymorphysme Mthfr Et Grossesse : A Propos D'un Cas Clinique
Authors: S. Bengalha , S. Jayi ; FZ . Fdili alaoui , Z . tazi ; Y . belhaj ; H. Chaara et Mly A . Melhouf
Volume: 10
Issue: 1
Pages: 5-9
Publication Date: 2026/01/28
Abstract:
During pregnancy there is a hypercoagulable state that is sometimes enhanced by genetic and/or acquired thrombosis risk factors. This enhances the risk of thromboembolic events and the risk of thrombosis in the vessels of the placenta and thus pregnancy losses. Among genetic risk factors, factor V Leiden responsible of spontaneous abortions, mainly late abortions. The rare antithrombin, protein C or protein S deficiencies are also implicated in some spontaneous abortions. Paternal genetic risk factors of thrombosis that could affect directly the foetus do not seem implicated in pregnancy losses. The MTHFR polymorphism is frequently identified during thrombophilia screening; however, its clinical significance remains highly controversial. Most professional societies do not recommend routine testing for MTHFR mutations in the evaluation of thrombophilia or recurrent pregnancy loss, as it does not independently predict thrombotic risk. We report the case of a 28-year-old pregnant woman, Mrs. F.Z. L , with a history of recurrent pregnancy loss, found to carry a heterozygous factor V Leiden mutation and a heterozygous MTHFR polymorphism . The patient was placed on therapeutic anticoagulation throughout the entire pregnancy, as prescribed by her internist.