Title: Effect of Chemotherapy on Liver and Kidney Functions in Breast Cancer Patients in Western Libya
Authors: Rabie Alwan Yahya , Azab Elsayed Azab , Ruqaya Al-Shaibani Al-Fitouri Al-Arousi
Volume: 10
Issue: 5
Pages: 40-46
Publication Date: 2026/05/28
Abstract:
Background: Chemotherapy targets rapidly dividing cells. While effective against cancer, it inadvertently damages healthy cells, leading to various systemic side effects. Objectives: This study evaluated changes in biochemical variables including liver enzymes (ALT, AST, ALP), renal markers (urea, creatinine, uric acid), and electrolytes in breast cancer patients at the National Cancer Institute of Sabratha. Materials and Methods: A comparative analysis was conducted involving 150 patients undergoing treatment and 100 healthy controls. Data were extracted from medical records and analyzed using SPSS to determine statistical significance. Results: Post-chemotherapy data revealed a significant increase (P < 0.01) in liver enzyme activities, concentrations of serum urea, creatinine, and uric acid. Additionally, sodium and chloride levels decreased significantly, while potassium levels rose. Conclusions: Chemotherapy induces marked biochemical alterations. These changes are significantly more pronounced following treatment compared to pre-treatment levels, highlighting the drug's impact on hepatic and renal functions.